We’ve put together this handy guide that goes into detail about the most important characters.

So, shall we begin then?

Her exploits bring her to national prominence, as she has survived every Ghostface onslaught.

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Fortunately, it’s not too long before she once again teams up with the core four.

Cox is popular for her role as Monica Geller on the NBC sitcomFriends.

InScream VI, Sam is now living with her sister Tara in New York City.

Courtney Cox as Gale on her phone in a scene from Scream 6

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She has now become increasingly over-protective of Tara, living in fear of Ghostface’s return.

She played Vanessa in the musical dramaIn The Heights.

InScream VI, Tara is now a freshman in college, living in New York.

scream 6 melissa barrerra

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Jenna Ortegahas become one of the biggest names in Hollywood in the 15 months after the previous film.

In 2022 alone she starred in films such asThe Fallout,X,American Carnage, andStudio 666.

Charlie stabs her towards the end ofScream 4and that was the last time she was seen.

Jenna Ortega as Tara Carpenter on a subway in Scream 6

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InScream VI, Kirby now works for the FBIand assists Sam and Tara in taking down the new Ghostface.

Her other movies includeI Love You, Beth Cooper,Remember the Titans,The Forger,andCustody.

Outside theScreamfranchise,Jasmin Savoy Brownis most known for her role as the teenaged Taissa in the Showtime seriesYellowjackets.

Kirby Reed looking intently at something off-camera in Scream VI

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InScream 5, it became obvious he was the least equipped to deal with the horrors of Ghostface.

Henry Czerny as Dr. Stone

Henry Czernyis another notable name on the Scream VI cast list.

He is also set to reprise hisMission: Impossiblerole inMission: Impossible - Dead Reckoning Part 1.

Jasmin Savoy Brown as Mindy on a subway in Scream 6

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Liberato is known for her role as Annie Cameron in the drama thrillerTrust.

Devyn Nekoda as Anika

Devyn Nekodaplays Anika, who is Mindy’s new girlfriend.

Nekoda is most known for her role as Riley in the hit Netflix seriesGinny & Georgia.

Mason Gooding wearing a hoodie outside as Chad in Scream 6

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She has also appeared in films and shows such asUtopia Falls,Backstage, andSneakerella.

Unbeknownst to everyone else, Sam is already seeing Danny romantically.

He has also appeared in films and shows includingTrainwreck,Overboard,Sirens, andThe Other Two.

Dermot Mulroney as Detective Bailey in Scream 6

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Weaving previously worked with directorsMatt Bettinelli-OlpinandTyler Gilletton the horror comedy Ready or Not.

Revolori first broke out with his role as Zero Moustafa inWes Anderson’sThe Grand Budapest Hotel.

He also played the role of Peter Parker’s rival Flash Thompson in the most recentSpider-Manfilms.

Henry Czerny as Dr. Stone in Scream 6

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Revolori’s other credits includeWillow,Dope,Servant, andThe French Dispatch.

Jack Champion as Ethan walking through a crime scene in Scream 6

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Liana Liberato as Quinn in Scream 6

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Devyn Nekoda as Anika pleading from a window in Scream 6

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Josh Segarra as Danny in Scream 6

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Samara Weaving as Laura on the phone in Scream 6

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Tony Revolori as Jason in Scream 6

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Movie

Scream VI